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Studies in glioblastoma, melanoma, and breast cancer have demonstrated that methionine restriction can suppress tumor growth, induce cell cycle arrest, and sensitize tumors to chemotherapy and immune checkpoint inhibitors

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The dorsal root ganglia (DRG) are particularly vulnerable and have been identified as the first site of neuropathology with the degeneration of the large sensory neurons and posterior columns, leading to the loss of position and vibration senses